Journal: Medicina

Article Title: Tibial Insufficiency Fracture with Characteristics of an Atypical Fracture: A Rare Case and Literature Review

doi: 10.3390/medicina60111814

Figure Lengend Snippet: Current published case reports on atypical tibial fractures associated with long-term bisphosphonate/antiresorptive use.

Article Snippet: The patient had been taking the bisphosphonate sodium risedronate (Actonel ® ; Sanofi-Aventis, Paris, France) 150 mg orally once a month for 4 years for osteoporosis, followed by intravenous administration of the bisphosphonate ibandronate sodium monohydrate (Bonviva ® ; Roche, Basel, Switzerland) 3 mg every three months for the subsequent 10 years.

Techniques:

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: Drug concentrations used to estimate EC 50 value.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques: Concentration Assay

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: EC 50 values for the tested drugs.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques:

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: Combinations of metamizole and risedronate sodium used in the study.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques:

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: The effect of risedronate sodium and metamizole on cell viability of the D-17 canine and U-2 OS human osteosarcoma cell lines, * values below control in the Dunnett test.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques: Control

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: The effect of combinations of risedronate sodium and metamizole on cell viability in the canine D-17 and human U-2 OS osteosarcoma cell lines, * values below control in the Dunnett test.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques: Control

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: The effect of risedronate sodium and metamizole on apoptosis in the canine and human osteosarcoma cell lines, * values below control in the Dunnett test.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques: Control

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: The effect of risedronate sodium and metamizole combinations on apoptosis in the canine D-17 and human U-2 OS osteosarcoma cell lines.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques:

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: The effect of risedronate sodium and metamizole on the cell cycle in the canine osteosarcoma D-17 cell line, * values below control in the Dunnett test.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques: Control

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: The effect of risedronate sodium and metamizole on the cell cycle in the U-2 OS human osteosarcoma cell line, * values below control in the Dunnett test.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques: Control

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: The effect of combinations of risedronate sodium with metamizole on the cell cycle in the canine osteosarcoma D-17 cell line, * values below control in the Dunnett test.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques: Control

Journal: Biomedicines

Article Title: Influence of Metamizole on Antitumour Activity of Risedronate Sodium in In Vitro Studies on Canine (D-17) and Human (U-2 OS) Osteosarcoma Cell Lines

doi: 10.3390/biomedicines12081869

Figure Lengend Snippet: The effect of combinations of risedronate sodium with metamizole on the cell cycle in the U-2 OS human osteosarcoma cell line, * values below control in the Dunnett test.

Article Snippet: Metamizole (meta) (Sigma-Aldrich, Taufkirchen, Germany) and risedronate sodium (rd) (Sigma-Aldrich, Taufkirchen, Germany) were dissolved in the culture media. presents the range of individual drug concentrations, selected based on their maximum serum concentration; in the case of both drugs, the type of solvent did not have a limiting effect on the selected concentrations.

Techniques: Control

Journal: Frontiers in Pharmacology

Article Title: The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model

doi: 10.3389/fphar.2024.1365151

Figure Lengend Snippet: Treatment groups and dosing.

Article Snippet: Risedronate sodium (Cat. No. SML0650), ethinyl estradiol (Cat No. E4876) and carboxymethylcellulose (CMC; Cat. No. C4888) were purchased from Sigma-Aldrich (St. Louis, MO).

Techniques: Concentration Assay

Journal: Frontiers in Pharmacology

Article Title: The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model

doi: 10.3389/fphar.2024.1365151

Figure Lengend Snippet: Longitudinal body, terminal body, and absolute organ weight measurements. (A) Mean weekly body weight measurements are plotted for each treatment group. Due to significant reductions in body weight, doses of EE2 were adjusted downward to 2.5 and 15 μg/kg body weight per day after three or four weeks of treatment for load one and load two animals. Animals in loads three and four only received the lowered doses. (B) Sham surgery and EE2 treatment groups had significantly lower body weight measurements at week 24, while all risedronate and black cohosh extract treatment groups showed no significant differences compared to OVX-vehicle control. (C–E) Uterine, liver and kidney weights at week 24 showed no significant differences associated with risedronate or black cohosh extract treatments compared to OVX-vehicle. Data plotted as mean ± SD. Significance was evaluated by one-way ANOVA with Sidak’s post-hoc for multiple comparisons. * Indicates difference vs. OVX-vehicle control; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001; n = 16–18. EE2 = ethinyl estradiol; BC = black cohosh extract; Ris = risedronate sodium; Veh = OVX-vehicle control.

Article Snippet: Risedronate sodium (Cat. No. SML0650), ethinyl estradiol (Cat No. E4876) and carboxymethylcellulose (CMC; Cat. No. C4888) were purchased from Sigma-Aldrich (St. Louis, MO).

Techniques:

Journal: Frontiers in Pharmacology

Article Title: The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model

doi: 10.3389/fphar.2024.1365151

Figure Lengend Snippet: BMD of femur, vertebrae and tibia following treatment with black cohosh extract and/or risedronate. (A) Longitudinal measurement of BMD at 0, 8, 16, and 24 weeks of treatment is plotted to show the effects of EE2, risedronate, black cohosh extract and risedronate + black cohosh extract combination treatments, with sham and vehicle data shown on each graph. Data plotted as mean ± SEM; n = 9–10. (B–D) BMD at week 24 was normalized to week 0 for each animal. After normalization, significant differences in BMD were associated with Hi EE2, Hi Ris and combined BC + Ris treatments, as compared to vehicle control. No statistically significant differences were observed between Lo Ris vs. Lo/Hi BC + Lo Ris or between Hi Ris vs. Lo/Hi BC + Hi Ris groups. Data plotted as mean ± SD. Significance was evaluated by one-way ANOVA with Sidak’s post-hoc for multiple comparisons. * Indicates difference vs. OVX-vehicle control; * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001; n = 14–18. EE2 = ethinyl estradiol; BC = black cohosh extract; Ris = risedronate sodium; Veh = OVX-vehicle control.

Article Snippet: Risedronate sodium (Cat. No. SML0650), ethinyl estradiol (Cat No. E4876) and carboxymethylcellulose (CMC; Cat. No. C4888) were purchased from Sigma-Aldrich (St. Louis, MO).

Techniques:

Journal: Cell Reports Methods

Article Title: RECOVER identifies synergistic drug combinations in vitro through sequential model optimization

doi: 10.1016/j.crmeth.2023.100599

Figure Lengend Snippet:

Article Snippet: Risedronate Sodium , Selleck , S1428.

Techniques: Software, Recombinant

Journal: Cell Reports Methods

Article Title: RECOVER identifies synergistic drug combinations in vitro through sequential model optimization

doi: 10.1016/j.crmeth.2023.100599

Figure Lengend Snippet:

Article Snippet: Risedronate Sodium , Selleck , S1428.

Techniques: Software, Recombinant